Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci
Identifieur interne : 000102 ( Main/Exploration ); précédent : 000101; suivant : 000103Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci
Auteurs : Marylyn D. Ritchie [États-Unis] ; Shefali S. Verma [États-Unis] ; Molly A. Hall [États-Unis] ; Robert J. Goodloe [États-Unis] ; Richard L. Berg [États-Unis] ; Dave S. Carrell [États-Unis] ; Christopher S. Carlson [États-Unis] ; Lin Chen [États-Unis] ; David R. Crosslin [États-Unis] ; Joshua C. Denny [États-Unis] ; Gail Jarvik [États-Unis] ; Rongling Li [États-Unis] ; James G. Linneman [États-Unis] ; Jyoti Pathak [États-Unis] ; Peggy Peissig [États-Unis] ; Luke V. Rasmussen [États-Unis] ; Andrea H. Ramirez [États-Unis] ; Xiaoming Wang [États-Unis] ; Russell A. Wilke [États-Unis] ; Wendy A. Wolf [États-Unis] ; Eric S. Torstenson [États-Unis] ; Stephen D. Turner [États-Unis] ; Catherine A. Mccarty [États-Unis]Source :
- Molecular Vision [ 1090-0535 ] ; 2014.
Abstract
Cataract is the leading cause of blindness in the world, and in the United States accounts for approximately 60% of Medicare costs related to vision. The purpose of this study was to identify genetic markers for age-related cataract through a genome-wide association study (GWAS).
In the electronic medical records and genomics (eMERGE) network, we ran an electronic phenotyping algorithm on individuals in each of five sites with electronic medical records linked to DNA biobanks. We performed a GWAS using 530,101 SNPs from the Illumina 660W-Quad in a total of 7,397 individuals (5,503 cases and 1,894 controls). We also performed an age-at-diagnosis case-only analysis.
We identified several statistically significant associations with age-related cataract (45 SNPs) as well as age at diagnosis (44 SNPs). The 45 SNPs associated with cataract at p<1×10−5 are in several interesting genes, including
This is the first genome-wide association study of age-related cataract, and several regions of interest have been identified. The eMERGE network has pioneered the exploration of genomic associations in biobanks linked to electronic health records, and this study is another example of the utility of such resources. Explorations of age-related cataract including validation and replication of the association results identified herein are needed in future studies.
Url:
PubMed: 25352737
PubMed Central: 4168835
Affiliations:
- États-Unis
- Dakota du Nord, Illinois, Maryland, Massachusetts, Minnesota, Pennsylvanie, Tennessee, Virginie, Washington (État), Wisconsin
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000168
- to stream Pmc, to step Curation: 000168
- to stream Pmc, to step Checkpoint: 000051
- to stream Ncbi, to step Merge: 000216
- to stream Ncbi, to step Curation: 000216
- to stream Ncbi, to step Checkpoint: 000216
- to stream Main, to step Merge: 000103
- to stream Main, to step Curation: 000102
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci</title><author><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D." last="Ritchie">Marylyn D. Ritchie</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park</wicri:cityArea></affiliation></author><author><name sortKey="Verma, Shefali S" sort="Verma, Shefali S" uniqKey="Verma S" first="Shefali S." last="Verma">Shefali S. Verma</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park</wicri:cityArea></affiliation></author><author><name sortKey="Hall, Molly A" sort="Hall, Molly A" uniqKey="Hall M" first="Molly A." last="Hall">Molly A. Hall</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park</wicri:cityArea></affiliation></author><author><name sortKey="Goodloe, Robert J" sort="Goodloe, Robert J" uniqKey="Goodloe R" first="Robert J." last="Goodloe">Robert J. Goodloe</name><affiliation wicri:level="2"><nlm:aff id="aff2">Center for Human Genetics Research, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Human Genetics Research, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Berg, Richard L" sort="Berg, Richard L" uniqKey="Berg R" first="Richard L." last="Berg">Richard L. Berg</name><affiliation wicri:level="2"><nlm:aff id="aff3">Biomedical Informatics Research Center, Biostatistics, Marshfield Clinic Research Foundation, Marshfield, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Biomedical Informatics Research Center, Biostatistics, Marshfield Clinic Research Foundation, Marshfield</wicri:cityArea></affiliation></author><author><name sortKey="Carrell, Dave S" sort="Carrell, Dave S" uniqKey="Carrell D" first="Dave S." last="Carrell">Dave S. Carrell</name><affiliation wicri:level="2"><nlm:aff id="aff4">Group Health Research Institute, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name><affiliation wicri:level="2"><nlm:aff id="aff5">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><affiliation wicri:level="2"><nlm:aff id="aff6">Ophthalmology, Marshfield Clinic Research Foundation, Marshfield, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Ophthalmology, Marshfield Clinic Research Foundation, Marshfield</wicri:cityArea></affiliation></author><author><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R." last="Crosslin">David R. Crosslin</name><affiliation wicri:level="2"><nlm:aff id="aff7">Division of Medical Genetics, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Medical Genetics, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8">Department of Biostatistics, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Biostatistics, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C." last="Denny">Joshua C. Denny</name><affiliation wicri:level="2"><nlm:aff id="aff9">Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Departments of Biomedical Informatics, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10">Department of Medicine, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Jarvik, Gail" sort="Jarvik, Gail" uniqKey="Jarvik G" first="Gail" last="Jarvik">Gail Jarvik</name><affiliation wicri:level="2"><nlm:aff id="aff7">Division of Medical Genetics, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Medical Genetics, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff11">Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Medicine and Genome Sciences, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Li, Rongling" sort="Li, Rongling" uniqKey="Li R" first="Rongling" last="Li">Rongling Li</name><affiliation wicri:level="2"><nlm:aff id="aff12">Office of Population Genomics, National Human Genome Research Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Office of Population Genomics, National Human Genome Research Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Linneman, James G" sort="Linneman, James G" uniqKey="Linneman J" first="James G." last="Linneman">James G. Linneman</name><affiliation wicri:level="2"><nlm:aff id="aff13">Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield</wicri:cityArea></affiliation></author><author><name sortKey="Pathak, Jyoti" sort="Pathak, Jyoti" uniqKey="Pathak J" first="Jyoti" last="Pathak">Jyoti Pathak</name><affiliation wicri:level="2"><nlm:aff id="aff14">Department of Biomedical Informatics, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Biomedical Informatics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Peissig, Peggy" sort="Peissig, Peggy" uniqKey="Peissig P" first="Peggy" last="Peissig">Peggy Peissig</name><affiliation wicri:level="2"><nlm:aff id="aff13">Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield</wicri:cityArea></affiliation></author><author><name sortKey="Rasmussen, Luke V" sort="Rasmussen, Luke V" uniqKey="Rasmussen L" first="Luke V." last="Rasmussen">Luke V. Rasmussen</name><affiliation wicri:level="2"><nlm:aff id="aff15">Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Ramirez, Andrea H" sort="Ramirez, Andrea H" uniqKey="Ramirez A" first="Andrea H." last="Ramirez">Andrea H. Ramirez</name><affiliation wicri:level="2"><nlm:aff id="aff10">Department of Medicine, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wang, Xiaoming" sort="Wang, Xiaoming" uniqKey="Wang X" first="Xiaoming" last="Wang">Xiaoming Wang</name><affiliation wicri:level="2"><nlm:aff id="aff9">Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Departments of Biomedical Informatics, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wilke, Russell A" sort="Wilke, Russell A" uniqKey="Wilke R" first="Russell A." last="Wilke">Russell A. Wilke</name><affiliation wicri:level="2"><nlm:aff id="aff9">Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Departments of Biomedical Informatics, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff16">IMAGENETICS at Sanford Medical Center, Fargo, ND and Department of Internal Medicine, University of North Dakota, Fargo, ND</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Dakota du Nord</region></placeName><wicri:cityArea>IMAGENETICS at Sanford Medical Center, Fargo, ND and Department of Internal Medicine, University of North Dakota, Fargo</wicri:cityArea></affiliation></author><author><name sortKey="Wolf, Wendy A" sort="Wolf, Wendy A" uniqKey="Wolf W" first="Wendy A." last="Wolf">Wendy A. Wolf</name><affiliation wicri:level="2"><nlm:aff id="aff17">Division of Genetics and Genomics, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Genetics and Genomics, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Torstenson, Eric S" sort="Torstenson, Eric S" uniqKey="Torstenson E" first="Eric S." last="Torstenson">Eric S. Torstenson</name><affiliation wicri:level="2"><nlm:aff id="aff2">Center for Human Genetics Research, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Human Genetics Research, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Turner, Stephen D" sort="Turner, Stephen D" uniqKey="Turner S" first="Stephen D." last="Turner">Stephen D. Turner</name><affiliation wicri:level="2"><nlm:aff id="aff18">Public Health Sciences, University of Virginia, Charlottesville, VA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Public Health Sciences, University of Virginia, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Mccarty, Catherine A" sort="Mccarty, Catherine A" uniqKey="Mccarty C" first="Catherine A." last="Mccarty">Catherine A. Mccarty</name><affiliation wicri:level="2"><nlm:aff id="aff19">Essentia Institute of Rural Health, Duluth, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Essentia Institute of Rural Health, Duluth</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25352737</idno><idno type="pmc">4168835</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168835</idno><idno type="RBID">PMC:4168835</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000168</idno><idno type="wicri:Area/Pmc/Curation">000168</idno><idno type="wicri:Area/Pmc/Checkpoint">000051</idno><idno type="wicri:Area/Ncbi/Merge">000216</idno><idno type="wicri:Area/Ncbi/Curation">000216</idno><idno type="wicri:Area/Ncbi/Checkpoint">000216</idno><idno type="wicri:Area/Main/Merge">000103</idno><idno type="wicri:Area/Main/Curation">000102</idno><idno type="wicri:Area/Main/Exploration">000102</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci</title><author><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D." last="Ritchie">Marylyn D. Ritchie</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park</wicri:cityArea></affiliation></author><author><name sortKey="Verma, Shefali S" sort="Verma, Shefali S" uniqKey="Verma S" first="Shefali S." last="Verma">Shefali S. Verma</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park</wicri:cityArea></affiliation></author><author><name sortKey="Hall, Molly A" sort="Hall, Molly A" uniqKey="Hall M" first="Molly A." last="Hall">Molly A. Hall</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park</wicri:cityArea></affiliation></author><author><name sortKey="Goodloe, Robert J" sort="Goodloe, Robert J" uniqKey="Goodloe R" first="Robert J." last="Goodloe">Robert J. Goodloe</name><affiliation wicri:level="2"><nlm:aff id="aff2">Center for Human Genetics Research, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Human Genetics Research, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Berg, Richard L" sort="Berg, Richard L" uniqKey="Berg R" first="Richard L." last="Berg">Richard L. Berg</name><affiliation wicri:level="2"><nlm:aff id="aff3">Biomedical Informatics Research Center, Biostatistics, Marshfield Clinic Research Foundation, Marshfield, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Biomedical Informatics Research Center, Biostatistics, Marshfield Clinic Research Foundation, Marshfield</wicri:cityArea></affiliation></author><author><name sortKey="Carrell, Dave S" sort="Carrell, Dave S" uniqKey="Carrell D" first="Dave S." last="Carrell">Dave S. Carrell</name><affiliation wicri:level="2"><nlm:aff id="aff4">Group Health Research Institute, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name><affiliation wicri:level="2"><nlm:aff id="aff5">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><affiliation wicri:level="2"><nlm:aff id="aff6">Ophthalmology, Marshfield Clinic Research Foundation, Marshfield, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Ophthalmology, Marshfield Clinic Research Foundation, Marshfield</wicri:cityArea></affiliation></author><author><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R." last="Crosslin">David R. Crosslin</name><affiliation wicri:level="2"><nlm:aff id="aff7">Division of Medical Genetics, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Medical Genetics, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8">Department of Biostatistics, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Biostatistics, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C." last="Denny">Joshua C. Denny</name><affiliation wicri:level="2"><nlm:aff id="aff9">Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Departments of Biomedical Informatics, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10">Department of Medicine, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Jarvik, Gail" sort="Jarvik, Gail" uniqKey="Jarvik G" first="Gail" last="Jarvik">Gail Jarvik</name><affiliation wicri:level="2"><nlm:aff id="aff7">Division of Medical Genetics, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Medical Genetics, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff11">Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Medicine and Genome Sciences, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Li, Rongling" sort="Li, Rongling" uniqKey="Li R" first="Rongling" last="Li">Rongling Li</name><affiliation wicri:level="2"><nlm:aff id="aff12">Office of Population Genomics, National Human Genome Research Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Office of Population Genomics, National Human Genome Research Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Linneman, James G" sort="Linneman, James G" uniqKey="Linneman J" first="James G." last="Linneman">James G. Linneman</name><affiliation wicri:level="2"><nlm:aff id="aff13">Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield</wicri:cityArea></affiliation></author><author><name sortKey="Pathak, Jyoti" sort="Pathak, Jyoti" uniqKey="Pathak J" first="Jyoti" last="Pathak">Jyoti Pathak</name><affiliation wicri:level="2"><nlm:aff id="aff14">Department of Biomedical Informatics, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Biomedical Informatics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Peissig, Peggy" sort="Peissig, Peggy" uniqKey="Peissig P" first="Peggy" last="Peissig">Peggy Peissig</name><affiliation wicri:level="2"><nlm:aff id="aff13">Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield</wicri:cityArea></affiliation></author><author><name sortKey="Rasmussen, Luke V" sort="Rasmussen, Luke V" uniqKey="Rasmussen L" first="Luke V." last="Rasmussen">Luke V. Rasmussen</name><affiliation wicri:level="2"><nlm:aff id="aff15">Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Ramirez, Andrea H" sort="Ramirez, Andrea H" uniqKey="Ramirez A" first="Andrea H." last="Ramirez">Andrea H. Ramirez</name><affiliation wicri:level="2"><nlm:aff id="aff10">Department of Medicine, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wang, Xiaoming" sort="Wang, Xiaoming" uniqKey="Wang X" first="Xiaoming" last="Wang">Xiaoming Wang</name><affiliation wicri:level="2"><nlm:aff id="aff9">Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Departments of Biomedical Informatics, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wilke, Russell A" sort="Wilke, Russell A" uniqKey="Wilke R" first="Russell A." last="Wilke">Russell A. Wilke</name><affiliation wicri:level="2"><nlm:aff id="aff9">Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Departments of Biomedical Informatics, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff16">IMAGENETICS at Sanford Medical Center, Fargo, ND and Department of Internal Medicine, University of North Dakota, Fargo, ND</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Dakota du Nord</region></placeName><wicri:cityArea>IMAGENETICS at Sanford Medical Center, Fargo, ND and Department of Internal Medicine, University of North Dakota, Fargo</wicri:cityArea></affiliation></author><author><name sortKey="Wolf, Wendy A" sort="Wolf, Wendy A" uniqKey="Wolf W" first="Wendy A." last="Wolf">Wendy A. Wolf</name><affiliation wicri:level="2"><nlm:aff id="aff17">Division of Genetics and Genomics, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Genetics and Genomics, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Torstenson, Eric S" sort="Torstenson, Eric S" uniqKey="Torstenson E" first="Eric S." last="Torstenson">Eric S. Torstenson</name><affiliation wicri:level="2"><nlm:aff id="aff2">Center for Human Genetics Research, Vanderbilt University, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Human Genetics Research, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Turner, Stephen D" sort="Turner, Stephen D" uniqKey="Turner S" first="Stephen D." last="Turner">Stephen D. Turner</name><affiliation wicri:level="2"><nlm:aff id="aff18">Public Health Sciences, University of Virginia, Charlottesville, VA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Public Health Sciences, University of Virginia, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Mccarty, Catherine A" sort="Mccarty, Catherine A" uniqKey="Mccarty C" first="Catherine A." last="Mccarty">Catherine A. Mccarty</name><affiliation wicri:level="2"><nlm:aff id="aff19">Essentia Institute of Rural Health, Duluth, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Essentia Institute of Rural Health, Duluth</wicri:cityArea></affiliation></author></analytic><series><title level="j">Molecular Vision</title><idno type="eISSN">1090-0535</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Cataract is the leading cause of blindness in the world, and in the United States accounts for approximately 60% of Medicare costs related to vision. The purpose of this study was to identify genetic markers for age-related cataract through a genome-wide association study (GWAS).</p></sec><sec><title>Methods</title><p>In the electronic medical records and genomics (eMERGE) network, we ran an electronic phenotyping algorithm on individuals in each of five sites with electronic medical records linked to DNA biobanks. We performed a GWAS using 530,101 SNPs from the Illumina 660W-Quad in a total of 7,397 individuals (5,503 cases and 1,894 controls). We also performed an age-at-diagnosis case-only analysis.</p></sec><sec><title>Results</title><p>We identified several statistically significant associations with age-related cataract (45 SNPs) as well as age at diagnosis (44 SNPs). The 45 SNPs associated with cataract at p<1×10<sup>−5</sup> are in several interesting genes, including <italic>ALDOB</italic>, <italic>MAP3K1</italic>, and <italic>MEF2C</italic>. All have potential biologic relationships with cataracts.</p></sec><sec><title>Conclusions</title><p>This is the first genome-wide association study of age-related cataract, and several regions of interest have been identified. The eMERGE network has pioneered the exploration of genomic associations in biobanks linked to electronic health records, and this study is another example of the utility of such resources. Explorations of age-related cataract including validation and replication of the association results identified herein are needed in future studies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Black, A" uniqKey="Black A">A Black</name></author><author><name sortKey="Wood, J" uniqKey="Wood J">J Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Congdon, N" uniqKey="Congdon N">N Congdon</name></author><author><name sortKey="O Olmain, B" uniqKey="O Olmain B">B O’Colmain</name></author><author><name sortKey="Klaver, Ccw" uniqKey="Klaver C">CCW Klaver</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name></author><author><name sortKey="Mu Oz, B" uniqKey="Mu Oz B">B Muñoz</name></author><author><name sortKey="Friedman, Ds" uniqKey="Friedman D">DS Friedman</name></author><author><name sortKey="Kempen, J" uniqKey="Kempen J">J Kempen</name></author><author><name sortKey="Taylor, Hr" uniqKey="Taylor H">HR Taylor</name></author><author><name sortKey="Mitchell, P" uniqKey="Mitchell P">P Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellwein, Lb" uniqKey="Ellwein L">LB Ellwein</name></author><author><name sortKey="Urato, Cj" uniqKey="Urato C">CJ Urato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Podgor, Mj" uniqKey="Podgor M">MJ Podgor</name></author><author><name sortKey="Cassel, Gh" uniqKey="Cassel G">GH Cassel</name></author><author><name sortKey="Kannel, Wb" uniqKey="Kannel W">WB Kannel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Minassian, Dc" uniqKey="Minassian D">DC Minassian</name></author><author><name sortKey="Mehra, V" uniqKey="Mehra V">V Mehra</name></author><author><name sortKey="Johnson, Gj" uniqKey="Johnson G">GJ Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="West, Sk" uniqKey="West S">SK West</name></author><author><name sortKey="Mu Oz, B" uniqKey="Mu Oz B">B Muñoz</name></author><author><name sortKey="Istre, J" uniqKey="Istre J">J Istre</name></author><author><name sortKey="Rubin, Gs" uniqKey="Rubin G">GS Rubin</name></author><author><name sortKey="Friedman, Sm" uniqKey="Friedman S">SM Friedman</name></author><author><name sortKey="Fried, Lp" uniqKey="Fried L">LP Fried</name></author><author><name sortKey="Bandeen Roche, K" uniqKey="Bandeen Roche K">K Bandeen-Roche</name></author><author><name sortKey="Schein, Od" uniqKey="Schein O">OD Schein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Jj" uniqKey="Wang J">JJ Wang</name></author><author><name sortKey="Mitchell, P" uniqKey="Mitchell P">P Mitchell</name></author><author><name sortKey="Simpson, Jm" uniqKey="Simpson J">JM Simpson</name></author><author><name sortKey="Cumming, Rg" uniqKey="Cumming R">RG Cumming</name></author><author><name sortKey="Smith, W" uniqKey="Smith W">W Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Sl" uniqKey="Williams S">SL Williams</name></author><author><name sortKey="Ferrigno, L" uniqKey="Ferrigno L">L Ferrigno</name></author><author><name sortKey="Mora, P" uniqKey="Mora P">P Mora</name></author><author><name sortKey="Rosmini, F" uniqKey="Rosmini F">F Rosmini</name></author><author><name sortKey="Maraini, G" uniqKey="Maraini G">G Maraini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reidy, A" uniqKey="Reidy A">A Reidy</name></author><author><name sortKey="Minassian, Dc" uniqKey="Minassian D">DC Minassian</name></author><author><name sortKey="Desai, P" uniqKey="Desai P">P Desai</name></author><author><name sortKey="Vafidis, G" uniqKey="Vafidis G">G Vafidis</name></author><author><name sortKey="Joseph, J" uniqKey="Joseph J">J Joseph</name></author><author><name sortKey="Farrow, S" uniqKey="Farrow S">S Farrow</name></author><author><name sortKey="Connolly, A" uniqKey="Connolly A">A Connolly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemons, Te" uniqKey="Clemons T">TE Clemons</name></author><author><name sortKey="Kurinij, N" uniqKey="Kurinij N">N Kurinij</name></author><author><name sortKey="Sperduto, Rd" uniqKey="Sperduto R">RD Sperduto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knudtson, Md" uniqKey="Knudtson M">MD Knudtson</name></author><author><name sortKey="Klein, Bek" uniqKey="Klein B">BEK Klein</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Congdon, N" uniqKey="Congdon N">N Congdon</name></author><author><name sortKey="Vingerling, Jr" uniqKey="Vingerling J">JR Vingerling</name></author><author><name sortKey="Klein, Bek" uniqKey="Klein B">BEK Klein</name></author><author><name sortKey="West, S" uniqKey="West S">S West</name></author><author><name sortKey="Friedman, Ds" uniqKey="Friedman D">DS Friedman</name></author><author><name sortKey="Kempen, J" uniqKey="Kempen J">J Kempen</name></author><author><name sortKey="O Olmain, B" uniqKey="O Olmain B">B O’Colmain</name></author><author><name sortKey="Wu, S Y" uniqKey="Wu S">S-Y Wu</name></author><author><name sortKey="Taylor, Hr" uniqKey="Taylor H">HR Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, Ma" uniqKey="Reddy M">MA Reddy</name></author><author><name sortKey="Francis, Pj" uniqKey="Francis P">PJ Francis</name></author><author><name sortKey="Berry, V" uniqKey="Berry V">V Berry</name></author><author><name sortKey="Bhattacharya, Ss" uniqKey="Bhattacharya S">SS Bhattacharya</name></author><author><name sortKey="Moore, At" uniqKey="Moore A">AT Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, At" uniqKey="Moore A">AT Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hejtmancik, Jf" uniqKey="Hejtmancik J">JF Hejtmancik</name></author><author><name sortKey="Kantorow, M" uniqKey="Kantorow M">M Kantorow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heiba, Im" uniqKey="Heiba I">IM Heiba</name></author><author><name sortKey="Elston, Rc" uniqKey="Elston R">RC Elston</name></author><author><name sortKey="Klein, Be" uniqKey="Klein B">BE Klein</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heiba, Im" uniqKey="Heiba I">IM Heiba</name></author><author><name sortKey="Elston, Rc" uniqKey="Elston R">RC Elston</name></author><author><name sortKey="Klein, Be" uniqKey="Klein B">BE Klein</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hammond, Cj" uniqKey="Hammond C">CJ Hammond</name></author><author><name sortKey="Duncan, Dd" uniqKey="Duncan D">DD Duncan</name></author><author><name sortKey="Snieder, H" uniqKey="Snieder H">H Snieder</name></author><author><name sortKey="De Lange, M" uniqKey="De Lange M">M De Lange</name></author><author><name sortKey="West, Sk" uniqKey="West S">SK West</name></author><author><name sortKey="Spector, Td" uniqKey="Spector T">TD Spector</name></author><author><name sortKey="Gilbert, Ce" uniqKey="Gilbert C">CE Gilbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hammond, Cj" uniqKey="Hammond C">CJ Hammond</name></author><author><name sortKey="Snieder, H" uniqKey="Snieder H">H Snieder</name></author><author><name sortKey="Spector, Td" uniqKey="Spector T">TD Spector</name></author><author><name sortKey="Gilbert, Ce" uniqKey="Gilbert C">CE Gilbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iyengar, Sk" uniqKey="Iyengar S">SK Iyengar</name></author><author><name sortKey="Klein, Bek" uniqKey="Klein B">BEK Klein</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name></author><author><name sortKey="Jun, G" uniqKey="Jun G">G Jun</name></author><author><name sortKey="Schick, Jh" uniqKey="Schick J">JH Schick</name></author><author><name sortKey="Millard, C" uniqKey="Millard C">C Millard</name></author><author><name sortKey="Liptak, R" uniqKey="Liptak R">R Liptak</name></author><author><name sortKey="Russo, K" uniqKey="Russo K">K Russo</name></author><author><name sortKey="Lee, Ke" uniqKey="Lee K">KE Lee</name></author><author><name sortKey="Elston, Rc" uniqKey="Elston R">RC Elston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okano, Y" uniqKey="Okano Y">Y Okano</name></author><author><name sortKey="Asada, M" uniqKey="Asada M">M Asada</name></author><author><name sortKey="Fujimoto, A" uniqKey="Fujimoto A">A Fujimoto</name></author><author><name sortKey="Ohtake, A" uniqKey="Ohtake A">A Ohtake</name></author><author><name sortKey="Murayama, K" uniqKey="Murayama K">K Murayama</name></author><author><name sortKey="Hsiao, Kj" uniqKey="Hsiao K">KJ Hsiao</name></author><author><name sortKey="Choeh, K" uniqKey="Choeh K">K Choeh</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Cao, Q" uniqKey="Cao Q">Q Cao</name></author><author><name sortKey="Reichardt, Jk" uniqKey="Reichardt J">JK Reichardt</name></author><author><name sortKey="Niihira, S" uniqKey="Niihira S">S Niihira</name></author><author><name sortKey="Imamura, T" uniqKey="Imamura T">T Imamura</name></author><author><name sortKey="Yamano, T" uniqKey="Yamano T">T Yamano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maraini, G" uniqKey="Maraini G">G Maraini</name></author><author><name sortKey="Hejtmancik, Jf" uniqKey="Hejtmancik J">JF Hejtmancik</name></author><author><name sortKey="Shiels, A" uniqKey="Shiels A">A Shiels</name></author><author><name sortKey="Mackay, Ds" uniqKey="Mackay D">DS Mackay</name></author><author><name sortKey="Aldigeri, R" uniqKey="Aldigeri R">R Aldigeri</name></author><author><name sortKey="Jiao, Xd" uniqKey="Jiao X">XD Jiao</name></author><author><name sortKey="Williams, Sl" uniqKey="Williams S">SL Williams</name></author><author><name sortKey="Sperduto, Rd" uniqKey="Sperduto R">RD Sperduto</name></author><author><name sortKey="Reed, G" uniqKey="Reed G">G Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zetterberg, M" uniqKey="Zetterberg M">M Zetterberg</name></author><author><name sortKey="Zetterberg, H" uniqKey="Zetterberg H">H Zetterberg</name></author><author><name sortKey="Palmer, M" uniqKey="Palmer M">M Palmér</name></author><author><name sortKey="Rymo, L" uniqKey="Rymo L">L Rymo</name></author><author><name sortKey="Blennow, K" uniqKey="Blennow K">K Blennow</name></author><author><name sortKey="Tasa, G" uniqKey="Tasa G">G Tasa</name></author><author><name sortKey="Juronen, E" uniqKey="Juronen E">E Juronen</name></author><author><name sortKey="Veromann, S" uniqKey="Veromann S">S Veromann</name></author><author><name sortKey="Teesalu, P" uniqKey="Teesalu P">P Teesalu</name></author><author><name sortKey="Karlsson, J O" uniqKey="Karlsson J">J-O Karlsson</name></author><author><name sortKey="Hoglund, K" uniqKey="Hoglund K">K Höglund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Juronen, E" uniqKey="Juronen E">E Juronen</name></author><author><name sortKey="Tasa, G" uniqKey="Tasa G">G Tasa</name></author><author><name sortKey="Veromann, S" uniqKey="Veromann S">S Veromann</name></author><author><name sortKey="Parts, L" uniqKey="Parts L">L Parts</name></author><author><name sortKey="Tiidla, A" uniqKey="Tiidla A">A Tiidla</name></author><author><name sortKey="Pulges, R" uniqKey="Pulges R">R Pulges</name></author><author><name sortKey="Panov, A" uniqKey="Panov A">A Panov</name></author><author><name sortKey="Soovere, L" uniqKey="Soovere L">L Soovere</name></author><author><name sortKey="Koka, K" uniqKey="Koka K">K Koka</name></author><author><name sortKey="Mikelsaar, Av" uniqKey="Mikelsaar A">AV Mikelsaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tamer, L" uniqKey="Tamer L">L Tamer</name></author><author><name sortKey="Yilmaz, A" uniqKey="Yilmaz A">A Yilmaz</name></author><author><name sortKey="Yildirim, H" uniqKey="Yildirim H">H Yildirim</name></author><author><name sortKey="Ayaz, L" uniqKey="Ayaz L">L Ayaz</name></author><author><name sortKey="Ates, Na" uniqKey="Ates N">NA Ates</name></author><author><name sortKey="Karakas, S" uniqKey="Karakas S">S Karakas</name></author><author><name sortKey="Oz, O" uniqKey="Oz O">O Oz</name></author><author><name sortKey="Yildirim, O" uniqKey="Yildirim O">O Yildirim</name></author><author><name sortKey="Atik, U" uniqKey="Atik U">U Atik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, D" uniqKey="Meyer D">D Meyer</name></author><author><name sortKey="Parkin, Dp" uniqKey="Parkin D">DP Parkin</name></author><author><name sortKey="Seifart, Hi" uniqKey="Seifart H">HI Seifart</name></author><author><name sortKey="Maritz, Js" uniqKey="Maritz J">JS Maritz</name></author><author><name sortKey="Engelbrecht, Ah" uniqKey="Engelbrecht A">AH Engelbrecht</name></author><author><name sortKey="Werely, Cj" uniqKey="Werely C">CJ Werely</name></author><author><name sortKey="Van Helden, Pd" uniqKey="Van Helden P">PD Van Helden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, S M" uniqKey="Lee S">S-M Lee</name></author><author><name sortKey="Tseng, L M" uniqKey="Tseng L">L-M Tseng</name></author><author><name sortKey="Li, A F" uniqKey="Li A">A-F Li</name></author><author><name sortKey="Liu, H C" uniqKey="Liu H">H-C Liu</name></author><author><name sortKey="Liu, T Y" uniqKey="Liu T">T-Y Liu</name></author><author><name sortKey="Chi, C W" uniqKey="Chi C">C-W Chi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shiels, A" uniqKey="Shiels A">A Shiels</name></author><author><name sortKey="Bennett, Tm" uniqKey="Bennett T">TM Bennett</name></author><author><name sortKey="Knopf, Hls" uniqKey="Knopf H">HLS Knopf</name></author><author><name sortKey="Maraini, G" uniqKey="Maraini G">G Maraini</name></author><author><name sortKey="Li, A" uniqKey="Li A">A Li</name></author><author><name sortKey="Jiao, X" uniqKey="Jiao X">X Jiao</name></author><author><name sortKey="Hejtmancik, Jf" uniqKey="Hejtmancik J">JF Hejtmancik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jun, G" uniqKey="Jun G">G Jun</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name></author><author><name sortKey="Klein, Bek" uniqKey="Klein B">BEK Klein</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name></author><author><name sortKey="Wang, Jj" uniqKey="Wang J">JJ Wang</name></author><author><name sortKey="Mitchell, P" uniqKey="Mitchell P">P Mitchell</name></author><author><name sortKey="Miao, H" uniqKey="Miao H">H Miao</name></author><author><name sortKey="Lee, Ke" uniqKey="Lee K">KE Lee</name></author><author><name sortKey="Joshi, T" uniqKey="Joshi T">T Joshi</name></author><author><name sortKey="Buck, M" uniqKey="Buck M">M Buck</name></author><author><name sortKey="Chugha, P" uniqKey="Chugha P">P Chugha</name></author><author><name sortKey="Bardenstein, D" uniqKey="Bardenstein D">D Bardenstein</name></author><author><name sortKey="Klein, Ap" uniqKey="Klein A">AP Klein</name></author><author><name sortKey="Bailey Wilson, Je" uniqKey="Bailey Wilson J">JE Bailey-Wilson</name></author><author><name sortKey="Gong, X" uniqKey="Gong X">X Gong</name></author><author><name sortKey="Spector, Td" uniqKey="Spector T">TD Spector</name></author><author><name sortKey="Andrew, T" uniqKey="Andrew T">T Andrew</name></author><author><name sortKey="Hammond, Cj" uniqKey="Hammond C">CJ Hammond</name></author><author><name sortKey="Elston, Rc" uniqKey="Elston R">RC Elston</name></author><author><name sortKey="Iyengar, Sk" uniqKey="Iyengar S">SK Iyengar</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glynn, Rj" uniqKey="Glynn R">RJ Glynn</name></author><author><name sortKey="Christen, Wg" uniqKey="Christen W">WG Christen</name></author><author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name></author><author><name sortKey="Bernheimer, J" uniqKey="Bernheimer J">J Bernheimer</name></author><author><name sortKey="Hennekens, Ch" uniqKey="Hennekens C">CH Hennekens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiller, R" uniqKey="Hiller R">R Hiller</name></author><author><name sortKey="Podgor, Mj" uniqKey="Podgor M">MJ Podgor</name></author><author><name sortKey="Sperduto, Rd" uniqKey="Sperduto R">RD Sperduto</name></author><author><name sortKey="Nowroozi, L" uniqKey="Nowroozi L">L Nowroozi</name></author><author><name sortKey="Wilson, Pw" uniqKey="Wilson P">PW Wilson</name></author><author><name sortKey="D Gostino, Rb" uniqKey="D Gostino R">RB D’Agostino</name></author><author><name sortKey="Colton, T" uniqKey="Colton T">T Colton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caulfield, Le" uniqKey="Caulfield L">LE Caulfield</name></author><author><name sortKey="West, Sk" uniqKey="West S">SK West</name></author><author><name sortKey="Barr N, Y" uniqKey="Barr N Y">Y Barrón</name></author><author><name sortKey="Cid Ruzafa, J" uniqKey="Cid Ruzafa J">J Cid-Ruzafa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaumberg, Da" uniqKey="Schaumberg D">DA Schaumberg</name></author><author><name sortKey="Glynn, Rj" uniqKey="Glynn R">RJ Glynn</name></author><author><name sortKey="Christen, Wg" uniqKey="Christen W">WG Christen</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author><author><name sortKey="Hennekens, Ch" uniqKey="Hennekens C">CH Hennekens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weintraub, Jm" uniqKey="Weintraub J">JM Weintraub</name></author><author><name sortKey="Willett, Wc" uniqKey="Willett W">WC Willett</name></author><author><name sortKey="Rosner, B" uniqKey="Rosner B">B Rosner</name></author><author><name sortKey="Colditz, Ga" uniqKey="Colditz G">GA Colditz</name></author><author><name sortKey="Seddon, Jm" uniqKey="Seddon J">JM Seddon</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacques, Pf" uniqKey="Jacques P">PF Jacques</name></author><author><name sortKey="Moeller, Sm" uniqKey="Moeller S">SM Moeller</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author><author><name sortKey="Chylack, Lt" uniqKey="Chylack L">LT Chylack</name></author><author><name sortKey="Rogers, G" uniqKey="Rogers G">G Rogers</name></author><author><name sortKey="Tung, W" uniqKey="Tung W">W Tung</name></author><author><name sortKey="Wolfe, Jk" uniqKey="Wolfe J">JK Wolfe</name></author><author><name sortKey="Willett, Wc" uniqKey="Willett W">WC Willett</name></author><author><name sortKey="Taylor, A" uniqKey="Taylor A">A Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuang, T M" uniqKey="Kuang T">T-M Kuang</name></author><author><name sortKey="Tsai, S Y" uniqKey="Tsai S">S-Y Tsai</name></author><author><name sortKey="Hsu, W M" uniqKey="Hsu W">W-M Hsu</name></author><author><name sortKey="Cheng, C Y" uniqKey="Cheng C">C-Y Cheng</name></author><author><name sortKey="Liu, J H" uniqKey="Liu J">J-H Liu</name></author><author><name sortKey="Chou, P" uniqKey="Chou P">P Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, Ls" uniqKey="Lim L">LS Lim</name></author><author><name sortKey="Tai, E S" uniqKey="Tai E">E-S Tai</name></author><author><name sortKey="Aung, T" uniqKey="Aung T">T Aung</name></author><author><name sortKey="Tay, Wt" uniqKey="Tay W">WT Tay</name></author><author><name sortKey="Saw, Sm" uniqKey="Saw S">SM Saw</name></author><author><name sortKey="Seielstad, M" uniqKey="Seielstad M">M Seielstad</name></author><author><name sortKey="Wong, Ty" uniqKey="Wong T">TY Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Congdon, N" uniqKey="Congdon N">N Congdon</name></author><author><name sortKey="Broman, Kw" uniqKey="Broman K">KW Broman</name></author><author><name sortKey="Lai, H" uniqKey="Lai H">H Lai</name></author><author><name sortKey="Munoz, B" uniqKey="Munoz B">B Munoz</name></author><author><name sortKey="Bowie, H" uniqKey="Bowie H">H Bowie</name></author><author><name sortKey="Gilber, D" uniqKey="Gilber D">D Gilber</name></author><author><name sortKey="Wojciechowski, R" uniqKey="Wojciechowski R">R Wojciechowski</name></author><author><name sortKey="Alston, C" uniqKey="Alston C">C Alston</name></author><author><name sortKey="West, Sk" uniqKey="West S">SK West</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, Ap" uniqKey="Klein A">AP Klein</name></author><author><name sortKey="Duggal, P" uniqKey="Duggal P">P Duggal</name></author><author><name sortKey="Lee, Ke" uniqKey="Lee K">KE Lee</name></author><author><name sortKey="O Eill, Ja" uniqKey="O Eill J">JA O’Neill</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name></author><author><name sortKey="Bailey Wilson, Je" uniqKey="Bailey Wilson J">JE Bailey-Wilson</name></author><author><name sortKey="Klein, Bek" uniqKey="Klein B">BEK Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saadat, M" uniqKey="Saadat M">M Saadat</name></author><author><name sortKey="Farvardin Jahromi, M" uniqKey="Farvardin Jahromi M">M Farvardin-Jahromi</name></author><author><name sortKey="Saadat, H" uniqKey="Saadat H">H Saadat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saadat, M" uniqKey="Saadat M">M Saadat</name></author><author><name sortKey="Farvardin Jahromi, M" uniqKey="Farvardin Jahromi M">M Farvardin-Jahromi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Chisholm, Rl" uniqKey="Chisholm R">RL Chisholm</name></author><author><name sortKey="Chute, Cg" uniqKey="Chute C">CG Chute</name></author><author><name sortKey="Kullo, Ij" uniqKey="Kullo I">IJ Kullo</name></author><author><name sortKey="Jarvik, Gp" uniqKey="Jarvik G">GP Jarvik</name></author><author><name sortKey="Larson, Eb" uniqKey="Larson E">EB Larson</name></author><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Masys, Dr" uniqKey="Masys D">DR Masys</name></author><author><name sortKey="Ritchie, Md" uniqKey="Ritchie M">MD Ritchie</name></author><author><name sortKey="Roden, Dm" uniqKey="Roden D">DM Roden</name></author><author><name sortKey="Struewing, Jp" uniqKey="Struewing J">JP Struewing</name></author><author><name sortKey="Wolf, Wa" uniqKey="Wolf W">WA Wolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peissig, Pl" uniqKey="Peissig P">PL Peissig</name></author><author><name sortKey="Rasmussen, Lv" uniqKey="Rasmussen L">LV Rasmussen</name></author><author><name sortKey="Berg, Rl" uniqKey="Berg R">RL Berg</name></author><author><name sortKey="Linneman, Jg" uniqKey="Linneman J">JG Linneman</name></author><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Waudby, C" uniqKey="Waudby C">C Waudby</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Denny, Jc" uniqKey="Denny J">JC Denny</name></author><author><name sortKey="Wilke, Ra" uniqKey="Wilke R">RA Wilke</name></author><author><name sortKey="Pathak, J" uniqKey="Pathak J">J Pathak</name></author><author><name sortKey="Carrell, D" uniqKey="Carrell D">D Carrell</name></author><author><name sortKey="Kho, An" uniqKey="Kho A">AN Kho</name></author><author><name sortKey="Starren, Jb" uniqKey="Starren J">JB Starren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rasmussen, Lv" uniqKey="Rasmussen L">LV Rasmussen</name></author><author><name sortKey="Peissig, Pl" uniqKey="Peissig P">PL Peissig</name></author><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Starren, J" uniqKey="Starren J">J Starren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuvich, Rl" uniqKey="Zuvich R">RL Zuvich</name></author><author><name sortKey="Armstrong, Ll" uniqKey="Armstrong L">LL Armstrong</name></author><author><name sortKey="Bielinski, Sj" uniqKey="Bielinski S">SJ Bielinski</name></author><author><name sortKey="Bradford, Y" uniqKey="Bradford Y">Y Bradford</name></author><author><name sortKey="Carlson, Cs" uniqKey="Carlson C">CS Carlson</name></author><author><name sortKey="Crawford, Dc" uniqKey="Crawford D">DC Crawford</name></author><author><name sortKey="Crenshaw, At" uniqKey="Crenshaw A">AT Crenshaw</name></author><author><name sortKey="De Andrade, M" uniqKey="De Andrade M">M De Andrade</name></author><author><name sortKey="Doheny, Kf" uniqKey="Doheny K">KF Doheny</name></author><author><name sortKey="Haines, Jl" uniqKey="Haines J">JL Haines</name></author><author><name sortKey="Hayes, Mg" uniqKey="Hayes M">MG Hayes</name></author><author><name sortKey="Jarvik, Gp" uniqKey="Jarvik G">GP Jarvik</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Kullo, Ij" uniqKey="Kullo I">IJ Kullo</name></author><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Ling, H" uniqKey="Ling H">H Ling</name></author><author><name sortKey="Manolio, Ta" uniqKey="Manolio T">TA Manolio</name></author><author><name sortKey="Matsumoto, Me" uniqKey="Matsumoto M">ME Matsumoto</name></author><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Mcdavid, An" uniqKey="Mcdavid A">AN McDavid</name></author><author><name sortKey="Mirel, Db" uniqKey="Mirel D">DB Mirel</name></author><author><name sortKey="Olson, Lm" uniqKey="Olson L">LM Olson</name></author><author><name sortKey="Paschall, Je" uniqKey="Paschall J">JE Paschall</name></author><author><name sortKey="Pugh, Ew" uniqKey="Pugh E">EW Pugh</name></author><author><name sortKey="Rasmussen, Lv" uniqKey="Rasmussen L">LV Rasmussen</name></author><author><name sortKey="Rasmussen Orvik, Lj" uniqKey="Rasmussen Orvik L">LJ Rasmussen‐Torvik</name></author><author><name sortKey="Turner, Sd" uniqKey="Turner S">SD Turner</name></author><author><name sortKey="Wilke, Ra" uniqKey="Wilke R">RA Wilke</name></author><author><name sortKey="Ritchie, Md" uniqKey="Ritchie M">MD Ritchie</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Purcell, S" uniqKey="Purcell S">S Purcell</name></author><author><name sortKey="Neale, B" uniqKey="Neale B">B Neale</name></author><author><name sortKey="Todd Brown, K" uniqKey="Todd Brown K">K Todd-Brown</name></author><author><name sortKey="Thomas, L" uniqKey="Thomas L">L Thomas</name></author><author><name sortKey="Ferreira, Mar" uniqKey="Ferreira M">MAR Ferreira</name></author><author><name sortKey="Bender, D" uniqKey="Bender D">D Bender</name></author><author><name sortKey="Maller, J" uniqKey="Maller J">J Maller</name></author><author><name sortKey="Sklar, P" uniqKey="Sklar P">P Sklar</name></author><author><name sortKey="De Bakker, Piw" uniqKey="De Bakker P">PIW De Bakker</name></author><author><name sortKey="Daly, Mj" uniqKey="Daly M">MJ Daly</name></author><author><name sortKey="Sham, Pc" uniqKey="Sham P">PC Sham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Al" uniqKey="Price A">AL Price</name></author><author><name sortKey="Patterson, Nj" uniqKey="Patterson N">NJ Patterson</name></author><author><name sortKey="Plenge, Rm" uniqKey="Plenge R">RM Plenge</name></author><author><name sortKey="Weinblatt, Me" uniqKey="Weinblatt M">ME Weinblatt</name></author><author><name sortKey="Shadick, Na" uniqKey="Shadick N">NA Shadick</name></author><author><name sortKey="Reich, D" uniqKey="Reich D">D Reich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verzi, Mp" uniqKey="Verzi M">MP Verzi</name></author><author><name sortKey="Agarwal, P" uniqKey="Agarwal P">P Agarwal</name></author><author><name sortKey="Brown, C" uniqKey="Brown C">C Brown</name></author><author><name sortKey="Mcculley, Dj" uniqKey="Mcculley D">DJ McCulley</name></author><author><name sortKey="Schwarz, Jj" uniqKey="Schwarz J">JJ Schwarz</name></author><author><name sortKey="Black, Bl" uniqKey="Black B">BL Black</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sitadevi, C" uniqKey="Sitadevi C">C Sitadevi</name></author><author><name sortKey="Ramaiah, Y" uniqKey="Ramaiah Y">Y Ramaiah</name></author><author><name sortKey="Askari, Z" uniqKey="Askari Z">Z Askari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, C" uniqKey="Jin C">C Jin</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Meng, Q" uniqKey="Meng Q">Q Meng</name></author><author><name sortKey="Carreira, V" uniqKey="Carreira V">V Carreira</name></author><author><name sortKey="Tam, Nnc" uniqKey="Tam N">NNC Tam</name></author><author><name sortKey="Geh, E" uniqKey="Geh E">E Geh</name></author><author><name sortKey="Karyala, S" uniqKey="Karyala S">S Karyala</name></author><author><name sortKey="Ho, S M" uniqKey="Ho S">S-M Ho</name></author><author><name sortKey="Zhou, X" uniqKey="Zhou X">X Zhou</name></author><author><name sortKey="Medvedovic, M" uniqKey="Medvedovic M">M Medvedovic</name></author><author><name sortKey="Xia, Y" uniqKey="Xia Y">Y Xia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasquale, Eb" uniqKey="Pasquale E">EB Pasquale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, H J" uniqKey="Lin H">H-J Lin</name></author><author><name sortKey="Huang, Y C" uniqKey="Huang Y">Y-C Huang</name></author><author><name sortKey="Lin, J M" uniqKey="Lin J">J-M Lin</name></author><author><name sortKey="Wu, J Y" uniqKey="Wu J">J-Y Wu</name></author><author><name sortKey="Chen, L A" uniqKey="Chen L">L-A Chen</name></author><author><name sortKey="Lin, C J" uniqKey="Lin C">C-J Lin</name></author><author><name sortKey="Tsui, Y P" uniqKey="Tsui Y">Y-P Tsui</name></author><author><name sortKey="Chen, C P" uniqKey="Chen C">C-P Chen</name></author><author><name sortKey="Tsai, F J" uniqKey="Tsai F">F-J Tsai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ionides, Ac" uniqKey="Ionides A">AC Ionides</name></author><author><name sortKey="Berry, V" uniqKey="Berry V">V Berry</name></author><author><name sortKey="Mackay, Ds" uniqKey="Mackay D">DS Mackay</name></author><author><name sortKey="Moore, At" uniqKey="Moore A">AT Moore</name></author><author><name sortKey="Bhattacharya, Ss" uniqKey="Bhattacharya S">SS Bhattacharya</name></author><author><name sortKey="Shiels, A" uniqKey="Shiels A">A Shiels</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Denny, Jc" uniqKey="Denny J">JC Denny</name></author><author><name sortKey="Crawford, Dc" uniqKey="Crawford D">DC Crawford</name></author><author><name sortKey="Ritchie, Md" uniqKey="Ritchie M">MD Ritchie</name></author><author><name sortKey="Bielinski, Sj" uniqKey="Bielinski S">SJ Bielinski</name></author><author><name sortKey="Basford, Ma" uniqKey="Basford M">MA Basford</name></author><author><name sortKey="Bradford, Y" uniqKey="Bradford Y">Y Bradford</name></author><author><name sortKey="Chai, Hs" uniqKey="Chai H">HS Chai</name></author><author><name sortKey="Bastarache, L" uniqKey="Bastarache L">L Bastarache</name></author><author><name sortKey="Zuvich, R" uniqKey="Zuvich R">R Zuvich</name></author><author><name sortKey="Peissig, P" uniqKey="Peissig P">P Peissig</name></author><author><name sortKey="Carrell, D" uniqKey="Carrell D">D Carrell</name></author><author><name sortKey="Ramirez, Ah" uniqKey="Ramirez A">AH Ramirez</name></author><author><name sortKey="Pathak, J" uniqKey="Pathak J">J Pathak</name></author><author><name sortKey="Wilke, Ra" uniqKey="Wilke R">RA Wilke</name></author><author><name sortKey="Rasmussen, L" uniqKey="Rasmussen L">L Rasmussen</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Pacheco, Ja" uniqKey="Pacheco J">JA Pacheco</name></author><author><name sortKey="Kho, An" uniqKey="Kho A">AN Kho</name></author><author><name sortKey="Hayes, Mg" uniqKey="Hayes M">MG Hayes</name></author><author><name sortKey="Weston, N" uniqKey="Weston N">N Weston</name></author><author><name sortKey="Matsumoto, M" uniqKey="Matsumoto M">M Matsumoto</name></author><author><name sortKey="Kopp, Pa" uniqKey="Kopp P">PA Kopp</name></author><author><name sortKey="Newton, Km" uniqKey="Newton K">KM Newton</name></author><author><name sortKey="Jarvik, Gp" uniqKey="Jarvik G">GP Jarvik</name></author><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Manolio, Ta" uniqKey="Manolio T">TA Manolio</name></author><author><name sortKey="Kullo, Ij" uniqKey="Kullo I">IJ Kullo</name></author><author><name sortKey="Chute, Cg" uniqKey="Chute C">CG Chute</name></author><author><name sortKey="Chisholm, Rl" uniqKey="Chisholm R">RL Chisholm</name></author><author><name sortKey="Larson, Eb" uniqKey="Larson E">EB Larson</name></author><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Masys, Dr" uniqKey="Masys D">DR Masys</name></author><author><name sortKey="Roden, Dm" uniqKey="Roden D">DM Roden</name></author><author><name sortKey="De Andrade, M" uniqKey="De Andrade M">M De Andrade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kullo, Ij" uniqKey="Kullo I">IJ Kullo</name></author><author><name sortKey="Ding, K" uniqKey="Ding K">K Ding</name></author><author><name sortKey="Shameer, K" uniqKey="Shameer K">K Shameer</name></author><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Jarvik, Gp" uniqKey="Jarvik G">GP Jarvik</name></author><author><name sortKey="Denny, Jc" uniqKey="Denny J">JC Denny</name></author><author><name sortKey="Ritchie, Md" uniqKey="Ritchie M">MD Ritchie</name></author><author><name sortKey="Ye, Z" uniqKey="Ye Z">Z Ye</name></author><author><name sortKey="Crosslin, Dr" uniqKey="Crosslin D">DR Crosslin</name></author><author><name sortKey="Chisholm, Rl" uniqKey="Chisholm R">RL Chisholm</name></author><author><name sortKey="Manolio, Ta" uniqKey="Manolio T">TA Manolio</name></author><author><name sortKey="Chute, Cg" uniqKey="Chute C">CG Chute</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Sd" uniqKey="Turner S">SD Turner</name></author><author><name sortKey="Berg, Rl" uniqKey="Berg R">RL Berg</name></author><author><name sortKey="Linneman, Jg" uniqKey="Linneman J">JG Linneman</name></author><author><name sortKey="Peissig, Pl" uniqKey="Peissig P">PL Peissig</name></author><author><name sortKey="Crawford, Dc" uniqKey="Crawford D">DC Crawford</name></author><author><name sortKey="Denny, Jc" uniqKey="Denny J">JC Denny</name></author><author><name sortKey="Roden, Dm" uniqKey="Roden D">DM Roden</name></author><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Ritchie, Md" uniqKey="Ritchie M">MD Ritchie</name></author><author><name sortKey="Wilke, Ra" uniqKey="Wilke R">RA Wilke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilke, Ra" uniqKey="Wilke R">RA Wilke</name></author><author><name sortKey="Berg, Rl" uniqKey="Berg R">RL Berg</name></author><author><name sortKey="Linneman, Jg" uniqKey="Linneman J">JG Linneman</name></author><author><name sortKey="Peissig, P" uniqKey="Peissig P">P Peissig</name></author><author><name sortKey="Starren, J" uniqKey="Starren J">J Starren</name></author><author><name sortKey="Ritchie, Md" uniqKey="Ritchie M">MD Ritchie</name></author><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Dakota du Nord</li><li>Illinois</li><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>Pennsylvanie</li><li>Tennessee</li><li>Virginie</li><li>Washington (État)</li><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D." last="Ritchie">Marylyn D. Ritchie</name></region><name sortKey="Berg, Richard L" sort="Berg, Richard L" uniqKey="Berg R" first="Richard L." last="Berg">Richard L. Berg</name><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name><name sortKey="Carrell, Dave S" sort="Carrell, Dave S" uniqKey="Carrell D" first="Dave S." last="Carrell">Dave S. Carrell</name><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R." last="Crosslin">David R. Crosslin</name><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R." last="Crosslin">David R. Crosslin</name><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C." last="Denny">Joshua C. Denny</name><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C." last="Denny">Joshua C. Denny</name><name sortKey="Goodloe, Robert J" sort="Goodloe, Robert J" uniqKey="Goodloe R" first="Robert J." last="Goodloe">Robert J. Goodloe</name><name sortKey="Hall, Molly A" sort="Hall, Molly A" uniqKey="Hall M" first="Molly A." last="Hall">Molly A. Hall</name><name sortKey="Jarvik, Gail" sort="Jarvik, Gail" uniqKey="Jarvik G" first="Gail" last="Jarvik">Gail Jarvik</name><name sortKey="Jarvik, Gail" sort="Jarvik, Gail" uniqKey="Jarvik G" first="Gail" last="Jarvik">Gail Jarvik</name><name sortKey="Li, Rongling" sort="Li, Rongling" uniqKey="Li R" first="Rongling" last="Li">Rongling Li</name><name sortKey="Linneman, James G" sort="Linneman, James G" uniqKey="Linneman J" first="James G." last="Linneman">James G. Linneman</name><name sortKey="Mccarty, Catherine A" sort="Mccarty, Catherine A" uniqKey="Mccarty C" first="Catherine A." last="Mccarty">Catherine A. Mccarty</name><name sortKey="Pathak, Jyoti" sort="Pathak, Jyoti" uniqKey="Pathak J" first="Jyoti" last="Pathak">Jyoti Pathak</name><name sortKey="Peissig, Peggy" sort="Peissig, Peggy" uniqKey="Peissig P" first="Peggy" last="Peissig">Peggy Peissig</name><name sortKey="Ramirez, Andrea H" sort="Ramirez, Andrea H" uniqKey="Ramirez A" first="Andrea H." last="Ramirez">Andrea H. Ramirez</name><name sortKey="Rasmussen, Luke V" sort="Rasmussen, Luke V" uniqKey="Rasmussen L" first="Luke V." last="Rasmussen">Luke V. Rasmussen</name><name sortKey="Torstenson, Eric S" sort="Torstenson, Eric S" uniqKey="Torstenson E" first="Eric S." last="Torstenson">Eric S. Torstenson</name><name sortKey="Turner, Stephen D" sort="Turner, Stephen D" uniqKey="Turner S" first="Stephen D." last="Turner">Stephen D. Turner</name><name sortKey="Verma, Shefali S" sort="Verma, Shefali S" uniqKey="Verma S" first="Shefali S." last="Verma">Shefali S. Verma</name><name sortKey="Wang, Xiaoming" sort="Wang, Xiaoming" uniqKey="Wang X" first="Xiaoming" last="Wang">Xiaoming Wang</name><name sortKey="Wilke, Russell A" sort="Wilke, Russell A" uniqKey="Wilke R" first="Russell A." last="Wilke">Russell A. Wilke</name><name sortKey="Wilke, Russell A" sort="Wilke, Russell A" uniqKey="Wilke R" first="Russell A." last="Wilke">Russell A. Wilke</name><name sortKey="Wolf, Wendy A" sort="Wolf, Wendy A" uniqKey="Wolf W" first="Wendy A." last="Wolf">Wendy A. Wolf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/OcrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000102 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000102 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= OcrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4168835
|texte= Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25352737" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a OcrV1
| This area was generated with Dilib version V0.6.32. |  |